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烯胺酮（或1,3-二羰基）和α-甘氨酸在乙酸酐中反应得到N-乙酰基吡咯的反应。

反应机理

反应实例

 (4). To 1 (573 mg, 2.74 mmol) in anhyd EtOH was added tetramethylammonium glycinate 2 (472 mg, 3.17 mmol) and the mixture was refluxed under Ar for 2 h. Evaporation in vacuo afforded 3 (yellow powder). Ac2O (7.3 mL) was added and the mixture was heated under Ar for 2 h at 150 ℃. Ac2O was removed in vacuo, aq workup (5% NaHCO3 wash) and chromatography (silica, CHCl3: hexane 1:1) gave 35 mg of 4 (58%).

【Cymerman-Craig J, Syn Comm., 1991, 27, 1971】

相关文献

1 Zav’yalov SI Izv Akad Nauk SSSR, Ser Khim Eng 1973 2505

2 Bach NJ J Med Chem 1980 23 481

3 Bemey D Helv Chim Acta 1982 65 1694

4 Ceccheti V J Heterocycl Chem 1982 19 1045

5 Cymerman-Craig J Syn Comm 1991 27 1971

6 Heron BM J Chem Soc Chem Comm 1999 289

7 Andrew RJ Tetrahedron 2000 56 7267

8 Ferreira VF Org Prep Proced Int 2001 33 411

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