杏耀公司找谁

TMS2NCa类催化剂存在下，胺加成到烯烃上得到氢胺化产物的反应。ω-氨基烯烃进行分子内的此反应可以到吡咯烷类化物。除了Ca可以催化此反应，镧系金属也可以很好催化此反应，对于催化，效果更好。

反应机理

反应实例

Pyrrolidine (4) (general procedure). Catalyst 2 (2–10 mol %) was added to 200–500 mg of aminoalkene 1 in 5 mL of PhH under Ar and the mixture was stirred until homogeneous. After quenching by exposure to air, rotary evaporation and bulb-to-bulb distillation gave 4, which was treated with HCl in

diethyl ether and analyzed by NMR.

【Hill MS, Barrett AGM, J Am Chem Soc., 2009, 131, 9670】

2-Benzylaminoethylbenzene (7). Styrene 5 (2.5 mmol) and benzylamine 6 (2.5 mmol) were treated under Ar with Ca{N(SiMe3)2}2 and the mixture was heated to 60 C for 48 h (faster with Sr{N(SiMe3)2}2]). After exposure to air and dilution with Et2O, the suspension was filtered through Celite and evaporated to afford 2-benzyl-aminoethylbenzene 7 (oil, 92%), purified by chromatography or vacuum distillation.

【Hill MS, Barrett AGM, J Am Chem Soc., 2009, 131, 12906】

相关文献

1 Marks TJ Acc Chem Res 2004 37 673

2 Hill MS J Am Chem Soc 2005 127 2042

3 Hill MS Organometal 2007 26 2953

4 Harder S Z Naturforsch 2008 63b 169

5 Hill MS, Barrett AGM J Am Chem Soc 2009 131 9670

6 Hill MS, Barrett AGM J Am Chem Soc 2009 131 12906

7 Harder S Chem Rev 2010 110 3852

编译自：Organic Syntheses Based On , 3RdEd, A. Hassner, Page 216-217.

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