杏耀总代平台_Meyers恶唑啉合成法

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手性恶唑啉作为手性引导因子或在亲核取代过程中加入手性助剂,进行不对称C-C键形成的反应。

反应机理

反应实例


参考文献

1. (a) Meyers, A. I.; Knaus, G.; Kamata, K. J. Am. Chem. Soc. 1974, 96, 268–270. While Albert I. Meyers was an assistant pressor at Wayne State Uversity, neighboring pharmaceutical firm Parke–Davis (Drs. George Moersch and Harry Crooks) donated several kilograms of (1S,2S)-(+)-2-amino-1-phenyl-1,3-propanediol (Meyers referred to it as the Parke–Davis diol), from which his with chiral oxazolines began. He taught at Colorado State since 1972. Meyers passed away in 2007.【Albert I. Meyers在韦恩州立大学任副教授的时候,派德药厂 ( George Moersch 和Harry Crooks博士)就利用他的方法通过手性恶唑啉合成数公斤 (1S,2S)-(+)-2-amino-1-phenyl-1,3-propanediol(Meyers称其为Parke–Davis二醇)。后一直到1972年在科罗拉多州立大学任教。Meyers2007年去世。】 (b) Meyers, A. I.; Knaus, G. J. Am. Chem. Soc. 1974, 96, 6508–6510. (c) Meyers, A. I.; Knaus, G. Tetrahedron Lett. 1974, 15, 1333–1336. (d) Meyers, A. I.; Whitten, C. E. J.Am. Chem. Soc. 1975, 97, 6266–6267. (e) Meyers, A. I.; Mihelich, E. D. J. Org.Chem. 1975, 40, 1186–1187. (f) Meyers, A. I.; Mihelich, E. D. Angew. Chem. Int. Ed.1976, 15, 270–271. (Review). (g) Meyers, A. I. Acc. Chem. Res. 1978, 11, 375–381.(Review).

2. Meyers, A. I.; Yamamoto, Y.; Mihelich, E. D.; Bell, R. A. J. Org. Chem. 1980, 45,2792–2796.

3. Meyers, A. I., Lutomski, K. A. In Asymmetric , Morrison, J. D. Ed.; Vol III,Part B, Chapter 3, Academic Press, 1983. (Review).

4. Reuman, M.; Meyers, A. I. Tetrahedron 1985, 41, 837–860. (Review).

5. Robichaud, A. J.; Meyers, A. I. J. Org. Chem. 1991, 56, 2607–2609.

6. Gant, T. G.; Meyers, A. I. Tetrahedron 1994, 50, 2297–2360. (Review).

7. Meyers, A. I. J. Heterocycl. Chem. 1998, 35, 991–1002. (Review).

8. Wolfe, J. P. Meyers Oxazoline Method. In in Heterocycl. Chemistry; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2005, pp 237–248. (Review).

9. Hogan, A.-M. L.; Tricotet, T.; Meek, A.; Khokhar, S. S.; O’Shea, D. F. J. Org. Chem.2008, 73, 6041–6044.

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