此反应是酸催化的三组分反应,醛,ß-酮酯和脲迅速容易地反应生成二氢嘧啶酮。二氢嘧啶酮是一种非常有用的。
反应机理:
机理的第一步通常认为是醛和脲先进行缩合,与 Mannich 缩合有些类似。生成的亚胺离子中间体作为亲电试剂,酮酯烯醇式对其进行亲核加成。生成的中间体的酮羰基与氨基进行缩合得到产品。
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